Disopan 2mg Tablet 10pcs

✔️ Uses of Disopan 2mg Tablet

• Seizures
• Panic Disorder
• Involuntary muscle spasms
• Restless leg syndrome

✔️ How does Disopan 2mg Tablet work?

Disopan 2mg Tablet belongs to benzodiazepines which work by enhancing the activity of GABA (gamma-aminobutyric acid) an inhibitory neurotransmitter (a chemical in the brain).

✔️ Side Effects of Disopan 2mg Tablet

• Sedation
• Drowsiness
• Dizziness
• Problems with walking and coordination
• Depression
• Fatigue, lethargy
• Problems with memory

✔️ Quick Suggestions:

• This medication has a high potential for addiction or dependence. Take it only as prescribed by your doctor in terms of dosage and duration.
• Be cautious of dizziness caused by this medication and avoid driving or engaging in activities that require mental focus until you understand its effects on you.
• It is advised to refrain from consuming alcohol as it can intensify dizziness and drowsiness.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Notify your doctor if you experience worsening anxiety, depression, anger, violent behavior, or mania while taking this medication. Regular exercise can be beneficial in reducing anxiety by releasing endorphins and improving sleep and self-image.
• Finding humor in daily life and watching light-hearted shows can help alleviate stress.
• Incorporating mindfulness practices such as yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction can enhance your mindfulness.
• Stay hydrated by drinking enough water and limiting or avoiding alcohol and caffeine to relieve anxiety.
• Include a diet rich in whole grains, vegetables, and fruits. Herbs like turmeric, ginger, and chamomile, known for their anti-inflammatory properties, can be incorporated into meals to reduce inflammation caused by anxiety disorders.
• Reduce intake of alcohol, caffeine, added sugar, high salt, and high-fat foods. Particularly, avoiding trans fats can help reduce inflammation.
• Include antioxidants in your daily diet, such as ashwagandha, omega-3 fatty acids, green tea, and lemon.
• Spending time with friends and family can be beneficial as having a strong social network may lower the risk of anxiety.
• Do not abruptly discontinue the medication without consulting your doctor, as it may lead to symptoms such as nausea, anxiety, agitation, flu-like symptoms, sweating, tremors, and confusion.

✔️ Indication of Disopan 2mg Tablet

Clonazepam is an antiepileptic medication used to prevent and treat seizures. It is classified as a benzodiazepine and also functions as an anti-convulsant. This drug helps control panic attacks by calming the nerves and the brain.

✔️ Pharmacology

Clonazepam is a medication that belongs to the benzodiazepine class and exhibits various pharmacological characteristics such as anticonvulsive, sedative, muscle relaxing, and anxiolytic actions. The central effects of benzodiazepines, including clonazepam, are primarily mediated by an increase in GABAergic neurotransmission at inhibitory synapses in the brain.

Benzodiazepines like clonazepam exert their effects by positively modulating the GABA receptor, which is a neurotransmitter receptor involved in inhibitory signaling in the brain. Clonazepam enhances the effect of GABA released in the synaptic cleft, leading to an increased influx of chloride ions through the transmembrane channels of the postsynaptic neuron. This influx of chloride ions hyperpolarizes the neuron, reducing its excitability and resulting in the observed anticonvulsant, sedative, muscle relaxing, and anxiolytic effects.

Additionally, there is evidence suggesting that clonazepam may impact serotonin in animals. It has been observed to suppress various types of paroxysmal activity, including spike and wave discharges seen in absence seizures (petit mal), slow spike wave activity, generalized spike wave patterns, as well as irregular spikes and waves. These effects have been demonstrated in animal studies and electroencephalographic investigations in humans.

Clonazepam has shown efficacy in repressing EEG abnormalities, both in generalized and localized epilepsies, according to the available studies. However, it's important to note that the specific effects and efficacy of clonazepam can vary depending on the individual and the underlying condition being treated. It is always recommended to consult with a healthcare professional for accurate information and guidance regarding the use of clonazepam or any other medication.

✔️ Dosage and Administration of Disopan 2mg Tablet

Adults with Seizure Disorders:

• Initial dose: Should not exceed 1.5 mg/day, divided into three doses.
• Dosage adjustment: The dose can be increased in increments of 0.5 to 1 mg every 3 days.
• Purpose of adjustment: Increase the dose until seizures are adequately controlled or until side effects prevent further increases.
• Maintenance dosage: This must be individualized for each patient based on their response.
• Maximum daily dose: The recommended maximum daily dose is 20 mg.

Adults with Panic Disorder:

• Initial dose: 0.25 mg given in two divided doses.
• Dosage adjustment: After 3 days, the dose can be increased to the target dose for most patients, which is 1 mg/day.

Pediatric Patients (up to 10 years of age or 30 kg of body weight):

• Initial dose: To minimize drowsiness, the initial dose should be between 0.01 and 0.03 mg/kg/day.
• Maximum initial dose: The initial dose should not exceed 0.05 mg/kg/day.
• Dosage frequency: The dose is given in two or three divided doses.

Take Disopan 2mg Tablet as advised by your physician. It can be taken with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

✔️ Interaction

Disopan 2mg Tablet can potentially interact with several medications:

• Opioid analgesics (such as alfentanil, buprenorphine, codeine, hydrocodone, and hydromorphone): Concurrent use of  Disopan 2mg Tablet with opioids can result in severe drowsiness, breathing problems, coma, and even death. Caution is advised when combining these medications.
• Antipsychotic medications (such as droperidol, and olanzapine): Combining  Disopan 2mg Tablet with antipsychotics can increase the risk of excessive sedation and respiratory depression. Close monitoring is recommended.
• Anesthesia medications (such as ketamine): Concurrent use of  Disopan 2mg Tablet with anesthesia medications may lead to enhanced sedative effects. Proper monitoring is important.
• Antidepressant medications (such as sodium oxybate): Combining  Disopan 2mg Tablet with certain antidepressants can result in increased sedation and respiratory depression. Careful monitoring is advised.
• Medications used to lower blood pressure (such as enalapril, amlodipine, felodipine, and indapamide):  Disopan 2mg Tablet may potentiate the blood pressure-lowering effects of these medications. Close monitoring of blood pressure is recommended.
• Acidity medication (cimetidine): Cimetidine may increase the blood levels of  Disopan 2mg Tablet, leading to an increased risk of side effects. Dose adjustment or monitoring may be necessary.
• Antibiotic medications (such as rifampicin, and fluconazole): Rifampicin may decrease the blood levels of  Disopan 2mg Tablet, while fluconazole may increase its blood levels. Dose adjustment or monitoring may be required.
• Anticonvulsants (such as diazepam, lorazepam): Concurrent use of  Disopan 2mg Tabletwith other anticonvulsants can potentiate sedation and respiratory depression. Caution is advised.

✔️ Contraindications

Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow-angle glaucoma.

✔️ Pregnancy & Lactation

There is a lack of sufficient and well-controlled studies on the use of Klonopin (Clonazepam) in pregnant women. The available human data regarding the risk of birth defects caused by this medication are inconclusive. In terms of neurodevelopmental effects, there is insufficient evidence in humans to assess the impact of benzodiazepine exposure during pregnancy.

Administering benzodiazepines, including Klonopin, immediately before or during childbirth can lead to a syndrome characterized by hypothermia, hypotonia, respiratory depression, and difficulties with feeding in the newborn. Furthermore, infants born to mothers who have taken benzodiazepines during the later stages of pregnancy can develop dependence and experience withdrawal symptoms during the postnatal period.

Data from studies involving other benzodiazepines suggest the possibility of adverse developmental effects, such as long-term effects on neurobehavioral and immunological function, in animals exposed to these medications prenatally.

The effects of Klonopin on breastfeeding infants and milk production are unknown. When considering the use of this medication, the potential benefits of breastfeeding in terms of infant development and health should be weighed against the mother's clinical need for therapy and any potential adverse effects on the breastfed infant arising from the medication itself or the underlying maternal condition.

✔️ Precautions & Warnings

• If you are allergic to clonazepam or any benzodiazepine medications (such as diazepam, chlordiazepoxide, bromazepam, or flurazepam), it is important not to take  Disopan 2mg Tablet. You should inform your doctor about any lung disease, glaucoma, muscle weakness (myasthenia gravis), sleep apnea (difficulty sleeping), depression, mood problems, suicidal thoughts or behavior, as well as liver or kidney problems that you may have.
• Taking  Disopan 2mg Tablet in combination with opioid medicines can lead to severe drowsiness, breathing difficulties, coma, and even death. Therefore, caution should be exercised when using these medications together.
• If you have a history of alcohol or drug abuse,  Disopan 2mg Tablet should be taken with extreme caution.
• It is important not to abruptly stop taking Disopan 2mg Tablet, as this can result in withdrawal symptoms. It is advisable to consult your doctor for guidance on gradually reducing the dosage and discontinuing the medication safely.

✔️ Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.